Keep It Up!


Keep It Up! is Now a Best Evidence Intervention!

Keep It Up! is now recognized as a best evidence intervention by the CDC. In order to receive this recognition, an HIV behavioral intervention must be scientifically rigorous and demonstrate significant and positive evidence of efficacy. Keep It Up! is one of only two interventions in the CDC’s compendium of effective behavioral interventions (EBIs) that is designed specifically for ethnically and racially diverse YMSM, and is the only one of the two that is delivered online. In addition, Keep It Up! is novel in linking an online HIV intervention to HIV and STI testing. 



  • Designed with guidance from ethnically diverse YMSM
  • Multimedia and interactive content delivery
  • Teaches useful skills for real-life scenarios
  • Highly rated by participants


  • Easy to use
  • Accessible online
  • Reinforces and expands on information provided by HIV prevention workers in time-limited interactions
  • Meets CDC’s prevention grant requirement to provide comprehensive HIV-related prevention services for HIV-negative persons


  • Based on the Information–Motivation–Behavioral Skills Model for HIV Preventive Behavior and principles of e-learning
  • Tested in 2 efficacy trials, 1 implementation trial, and counting
  • Among 901 YMSM in 3 cities, significantly reduced recent condomless anal sex from 70% to 40% in the KIU! arm
    • Reductions were maintained for 12 months post intervention
    • This represented a 17% greater decrease than an active control arm
    • Also reduced STI rates by 40% compared to the control
KIU! 1.0 (2009 – 2010) Pilot Randomized Controlled Trial 102 YMSM (ages 18-24) in Chicago  Read Results
KIU! 1.5 (2012 – 2014) Service Implementation 343 YMSM (ages 15-24) in Chicago  Read Results
KIU! 2.0 (2013 – 2017) Randomized Controlled Trial 901 YMSM (ages 18-29) in Chicago, NY and Atlanta  Read Results
KIU! 2.5 (2017 – Present) Service Implementation Ongoing in Jackson, MS  —


Additional information

Q: Can my agency and/or I use Keep It Up! now?

A: We recently received funding from the National Institute of Mental Health (NIMH) to make KIU! available in nearly 50 U.S. counties to community-based organizations, health departments, and young men who would like to use it. We will soon release a request for applications (RFA) for community based organizations in the eligible counties. Please sign up below to receive updates about KIU! and the upcoming RFA.

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